We recently described that activated neutrophils shed the ectodomain of SIRL-1, thereby releasing soluble SIRL-1 (sSIRL-1). Signal inhibitory receptor on leukocytes-1 (SIRL-1), encoded by the gene VSTM1, is an immune inhibitory receptor expressed on human granulocytes and monocytes. 91815608, The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: This work was supported by Amsterdam UMC, University of Amsterdam, and by a Vici grant from the Netherlands Organization for Scientific Research (NWO, grant no.
Received: OctoAccepted: FebruPublished: April 13, 2023Ĭopyright: © 2023 von Richthofen et al. PLoS ONE 18(4):Įditor: Sumit Kumar Hira, The University of Burdwan, INDIA Citation: von Richthofen HJ, Hafkamp FMJ, van Haperen A, de Jong EC, Meyaard L (2023) VSTM1-v2 does not drive human Th17 cell differentiation: A replication study.
